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Menu
Home PageAll MoleculesCD27
CD27
CD27 Overview
| English Name | CD27 antigen | Approved Drugs | 0 |
| Drugs in Clinical Trials | 4 | Target Synonym | CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7 |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | CD27 antigen |
| Target Synonym | CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 4 |
| Highest Development Stage | Phase 2 Clinical |
CD27 Product List
- Product Category
Protein (6)
- Product Status
Launched (6)
- Species
Human (4)Cynomolgus / Rhesus macaque (1)Mouse (1)
- Tag
Fc Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (3)His Tag (1)
- Conjugate
Unconjugated (5)Biotin-labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT CD7-H522b |  Human | HEK293 | Human CD27 / TNFRSF7 Protein, His Tag (MALS verified) |  |  |  |
HOT CD7-H5254 | Human | HEK293 | Human CD27 / TNFRSF7 Protein, Fc Tag (MALS verified) |  | | |
HOT CD7-H5257 | Human | HEK293 | Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified) |  | | |
HOT TN7-H82F6 | Human | HEK293 | Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™ |  | | |
HOT CD7-M5252 |  Mouse | HEK293 | Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified) |  | | |
HOT CD7-C5259 |  Cynomolgus / Rhesus macaque | HEK293 | Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified) |  | | |
Total: 6
- 1
CD27 Background
CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.
CD27 Synonyms
CD27,TNFRSF7,S152,T14,Tp55
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Boserolimab | MK-5890 | Phase 2 Clinical | Aduro Biotech Europe Bv | Solid tumours; Triple Negative Breast Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| Varlilumab | CDX-1127 | Phase 2 Clinical | Celldex Therapeutics | Lung Neoplasms; Lymphoma, Primary Effusion; Cholangiocarcinoma; Prostatic Neoplasms; Bile Duct Neoplasms; Urologic Neoplasms; Astrocytoma; Burkitt Lymphoma; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Lymphoma, T-Cell; Plasmablastic Lymphoma; Urogenital Neoplasms; Glioma; Leukemia, Lymphocytic, Chronic, B-Cell; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Leukemia, T-Cell; Large intestine neoplasm; Central Nervous System Lymphoma; Skin Neoplasms; Solid tumours; Kidney Neoplasms; Head and Neck Neoplasms; Lymphoma, B-Cell, Marginal Zone; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Lymphomatoid Granulomatosis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, B-Cell; Glioblastoma; Neoplasms; Kidney Diseases; Triple Negative Breast Neoplasms; Hormone-Resistant Prostate Neoplasms; Urinary Bladder Neoplasms; Urologic Diseases; Oligodendroglioma; Lymphoma, Mantle-Cell | Details |
| LOR-S03 | CDX-527 | Phase 1 Clinical | Celldex Therapeutics | Ovarian Neoplasms; Liver Neoplasms; Solid tumours; Head and Neck Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Breast Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| Anti-CD27 monoclonal antibody (Aduro Biotech) | BION-1402 | Phase 1 Clinical | Aduro Biotech Inc | Neoplasms | Details |
Product Reviews
W***I2025-11-07
0People LikeThis protein is used for binding activity experiments. According to pre-confirmation data, accuracy, precision, durability, linearity, and range all meet the validation acceptance criteria and can be used as a translational research.
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