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Page d'accueilToutes les moléculesCD46
CD46
CD46 Informations sur la molécule
| Nom anglais | Membrane cofactor protein | Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 5 | Alias de la cible | TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544 |
| Phase de R&D la plus avancée | Phase 2 Clinical | ||
| Nom anglais | Membrane cofactor protein |
| Alias de la cible | TLX，MCP，CD46，CD46 Molecule，Membrane Cofactor Protein (CD46， Trophoblast-Lymphocyte Cross-Reactive Antigen)，Antigen Identified By Monoclonal Antibody TRA-2-10，CD46 Molecule， Complement Regulatory Protein，CD46 Antigen， Complement Regulatory Protein，Trophoblast Leukocyte Common Antigen，MIC10，Trophoblast-Lymphocyte Cross-Reactive Antigen，Complement Membrane Cofactor Protein，Trophoblast Leucocyte Common Antigen，Measles Virus Receptor，CD46 Antigen，TRA2.10，AHUS2，Membrane cofactor protein，MGC26544 |
| Nombre de médicaments commercialisés | 0 |
| Nombre de médicaments cliniques | 5 |
| Phase de R&D la plus avancée | Phase 2 Clinical |
CD46 Liste de produits
- Attribut
Protein (5)
- Bibliothèque de produits
En ligne (5)
- Espèces
Human (5)
- Étiquette
His Tag (4)Fc Tag (1)
- Marqueur
Unconjugated (2)FITC Labeled (1)APC Labeled (1)PE Labeled (1)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
CD6-H5226 |  Human | HEK293 | Human CD46 Protein, His Tag (MALS verified) |  |  |  |  Ajouter au panier |
CD6-H5254 | Human | HEK293 | Human CD46 Protein, Fc Tag (MALS verified) |  | | | Ajouter au panier |
CD6-HA224 | Human | HEK293 | APC-Labeled Human CD46 Protein, His Tag |  | Ajouter au panier | ||
CD6-HF223 | Human | HEK293 | FITC-Labeled Human CD46 Protein, His Tag |  | | Ajouter au panier | |
CD6-HP223 | Human | HEK293 | PE-Labeled Human CD46 Protein, His Tag |  | Ajouter au panier |
Quantité totale5
- 1
CD46Contexte de la molécule
Complement regulatory protein CD46 is also known as membrane Cofactor Protein (MCP), is a type I membrane protein and is a regulatory part of the complement system. CD46 is expressed by all cells except erythrocytes. MCP acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue, and also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype.
CD46Alias de la molécule
CD46,AHUS2,MCP,MIC10,TLX,TRA2.10
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| Anti-CD46 antibody drug conjugate (Fortis Therapeutics) | FOR-46; FG-3246 | Phase 2 Clinical | University Of California San Diego | Prostatic Neoplasms, Castration-Resistant; Multiple Myeloma; Prostatic Neoplasms | Details |
| Enadenotucirev | ColoAd-1; Oncolytic Ad11/Ad3 | Phase 1 Clinical | Akamis Bio Ltd | Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Rectal Neoplasms; Colonic Neoplasms; Neoplasms, Glandular and Epithelial; Urinary Bladder Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| AugmAb | BRM-132 | Phase 1 Clinical | Neoplasms; Lymphoma, Non-Hodgkin | Details | |
| YS-5 | YS-5 | Phase 1 Clinical | Fortis Therapeutics Inc, United States Department Of Defense | Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
| FG-3180 | 89Zr-DFO-YS-5; 89Zr-DFO-YS5 | Phase 1 Clinical | Fortis Therapeutics Inc | Multiple Myeloma; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms | Details |
- Informations sur la molécule
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