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Menu
Home PageAll MoleculesDR3
DR3
DR3 Product List
- Product Category
Protein (7)Cell (1)
- Product Status
Launched (8)
- Species
Cynomolgus (2)Human (5)Mouse (1)
- Tag
Fc Tag (2)His Tag (3)- (1)Fc Tag & Avi Tag (1)His Tag & Avi Tag (1)
- Conjugate
Unconjugated (5)- (1)Biotin-labeled (2)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT DR3-H5253 |  Human | HEK293 | Human DR3 Protein, Fc Tag, low endotoxin (MALS verified) |  |  |  |
HOT DR3-H82E3 | Human | HEK293 | Biotinylated Human DR3 / TNFRSF25 Protein, His,Avitag™ (MALS verified) |  | | |
HOT TN5-H52H3 | Human | HEK293 | Human DR3 / TNFRSF25 Protein, His Tag, low endotoxin (MALS verified) |  | | |
DR3-H82F3 | Human | HEK293 | Biotinylated Human DR3 / TNFRSF25 Protein, Fc,Avitag™ (MALS verified) |  | | |
SCJUR-STF178 | Human | Jurkat | Human DR3 (TL1A receptor) (Luc) Jurkat Reporter Cell |  | ||
DR3-M52H3 |  Mouse | HEK293 | Mouse DR3 / TNFRSF25 Protein, His Tag (HPLC & SPR verified) |  | |  |
DR3-C52H3 |  Cynomolgus | HEK293 | Cynomolgus DR3 / TNFRSF25 Protein, His Tag (SPR verified) |  | | |
TN5-C5257 | Cynomolgus | HEK293 | Cynomolgus DR3 / TNFRSF25 Protein, Fc Tag, low endotoxin |  | |
Total: 8
- 1
DR3 Background
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Ontamalimab | SHP-647; PF-00547659; PF-547659 | Phase 3 Clinical | Pfizer Inc | Ileitis; Colitis, Ulcerative; Crohn Disease | Details |
| Vedolizumab biosimilar (Polpharma Biologics) | PB-016 | Phase 3 Clinical | Polpharma Biologics Sa | Pouchitis; Colitis, Ulcerative; Crohn Disease | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Vedolizumab | MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02 | Approved | Millennium Pharmaceuticals Inc | 安吉优, Entyvio | United States | Colitis, Ulcerative; Crohn Disease | Takeda Pharmaceuticals USA Inc | 2014-05-20 | Celiac Disease; Carcinoma, Non-Small-Cell Lung; Melanoma; Crohn Disease; Gastritis; Urogenital Neoplasms; Colitis, Ulcerative; Cholangitis, Sclerosing; Pediatric ulcerative colitis; Solid tumours; Colitis; Pouchitis; Neoplasms; Pediatric Crohn's disease; Inflammatory Bowel Diseases; HIV Infections; Hematopoietic stem cell transplantation (HSCT) | Details |
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