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EDNRB
EDNRB Informations sur la molécule
| Nom anglais | Endothelin receptor type B | Nombre de médicaments commercialisés | 5 |
| Nombre de médicaments cliniques | 3 | Alias de la cible | Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B |
| Phase de R&D la plus avancée | Approved | ||
| Nom anglais | Endothelin receptor type B |
| Alias de la cible | Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B |
| Nombre de médicaments commercialisés | 5 |
| Nombre de médicaments cliniques | 3 |
| Phase de R&D la plus avancée | Approved |
EDNRB Liste de produits
- Attribut
Protein (4)
- Bibliothèque de produits
En ligne (4)
- Espèces
Human (4)
- Étiquette
- (2)GFP Tag (1)His Tag & Flag Tag (1)
- Marqueur
Unconjugated (3)GFP Fusion (1)
| Numéro de produit | Espèces | Système d'expression | Description du produit | Structure protéique | Pureté | Caractéristiques | Pré-commande/Commande |
|---|---|---|---|---|---|---|---|
EDB-H52D3 |  Human | HEK293 | Human EDNRB Protein, Flag,His Tag (Detergent) |  |  |  |  Ajouter au panier |
EDB-H52D4 | Human | E. coli | Human EDNRB Full Length Protein, His,Flag Tag (Detergent) |  | | Ajouter au panier | |
EDB-H52P7 | Human | HEK293 | Human EDNRB Full Length Protein (VLP) | | Ajouter au panier | ||
EDB-HF2G4 | Human | HEK293 | Fluorescent Human EDNRB Full Length Protein (VLP) | | Ajouter au panier |
Quantité totale4
- 1
EDNRBContexte de la molécule
Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.
EDNRBAlias de la molécule
EDNRB,endothelin receptor type B,ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
Informations sur les médicaments cliniques
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Indication | Essai clinique |
|---|---|---|---|---|---|
| VRP-1620 | VRP-1620 | Phase 3 Clinical | University Of Illinois | Breast Neoplasms | Details |
| Vodudeutentan | ENB-003; ENB-006 | Phase 2 Clinical | Enb Therapeutics Inc | Ovarian Neoplasms; Solid tumours; Pancreatic Neoplasms; Neoplasms; Melanoma | Details |
| BQ-788 | BQ-788 | Phase 1 Clinical | Merck Serono | Hypertension; Cardiovascular Diseases; Melanoma | Details |
Informations sur les médicaments commercialisés
| Nom anglais | Code de recherche | Phase de R&D | Entreprise | Plus ancien nom de marque | Pays d'approbation le plus ancien | Indication la plus ancienne | Société d'approbation la plus ancienne | Date d'approbation la plus ancienne | Indication | Essai clinique |
|---|---|---|---|---|---|---|---|---|---|---|
| Sovateltide | IRL-1620; PMZ-1620; SPI-1620 | Approved | University Of Illinois At Chicago | Tyvalzi | India | Stroke | Pharmazz Inc | 2023-05-31 | Biliary Tract Neoplasms; Brain Ischemia; Carcinoma; Spinal Cord Injuries; Asphyxia Neonatorum; Brain Diseases; Stroke; Ischemic Stroke; Dementia; Alzheimer Disease; Hypoxia-Ischemia, Brain; Cerebral Infarction; Carcinoma, Non-Small-Cell Lung | Details |
| Macitentan/Tadalafil | Approved | Actelion Pharmaceuticals Ltd | OPSYNVI, Yuvanci | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2024-03-22 | Phenylketonurias; Pulmonary Arterial Hypertension | Details | |
| Bosentan Hydrate | ACT-050088; HGP-1206; Ro-47-0203; Ro-47-0203/029; Ro-47-0203/039 | Approved | F. Hoffmann-La Roche Ltd | Stayveer, 全可利, Tracleer | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Ltd | 2001-11-20 | Hepatopulmonary Syndrome; Diabetes Mellitus; Heart Defects, Congenital; Anemia, Sickle Cell; Persistent Fetal Circulation Syndrome; Ulcer; Glaucoma; Sleep Apnea Syndromes; Pulmonary Arterial Hypertension; Coronary Vasospasm; Lung Diseases, Interstitial; Hypertension, Pulmonary; Pulmonary Fibrosis; Hypertension; Fibrosis; Chronic thromboembolic pulmonary hypertension; Liver Cirrhosis; Sarcoidosis; Scleroderma, Systemic; Idiopathic Pulmonary Fibrosis; Diabetes Mellitus, Type 2; Heart Septal Defects, Atrial | Details |
| Macitentan | ACT-064992; Actelion-1; JNJ-67896062 | Approved | Actelion Pharmaceuticals Ltd | Zependo, Opsumit, 傲朴舒 | United States | Pulmonary Arterial Hypertension | Actelion Pharmaceuticals Us Inc | 2013-10-18 | Hypertension, Pulmonary; Pulmonary Embolism; Heart Failure, Diastolic; Heart Failure; Scleroderma, Systemic; Chronic thromboembolic pulmonary hypertension; Idiopathic Pulmonary Fibrosis; Glioblastoma; Thromboembolism; Pulmonary Arterial Hypertension; Scleroderma-associated interstitial lung diseases; Eisenmenger Complex; Ulcer; Heart Defects, Congenital; Anemia, Sickle Cell; Chronic Disease | Details |
| Aprocitentan | JNJ-2820; ACT-132577; AC-080 | Approved | Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd | TRYVIO, JERAYGO | United States | Hypertension | Idorsia Pharmaceuticals Ltd | 2024-03-19 | Hypertension; Essential Hypertension; Hepatic Insufficiency; Renal Insufficiency, Chronic | Details |
- Informations sur la molécule
- Liste de produits
- Informations sur les médicaments commercialisés
- Informations sur les médicaments cliniques
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