GDNF

GDNF Informations sur la molécule

Nom anglais	Glial cell line-derived neurotrophic factors	Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5	Alias de la cible	Glial Cell Line-Derived Neurotrophic Factors
Phase de R&D la plus avancée	NDA/BLA

Nom anglais	Glial cell line-derived neurotrophic factors
Alias de la cible	Glial Cell Line-Derived Neurotrophic Factors
Nombre de médicaments commercialisés	0
Nombre de médicaments cliniques	5
Phase de R&D la plus avancée	NDA/BLA

GDNF Liste de produits

Attribut
Protein (5)
Bibliothèque de produits
En ligne (5)
Espèces
Human (4)Mouse (1)
Étiquette
Tag Free (4)His Tag (1)
Marqueur
Unconjugated (5)

Numéro de produit	Espèces	Système d'expression	Description du produit	Pré-commande/Commande
GDF-H5118	Human	E. coli	Human GDNF / ATF / hGDNF Protein (E. coli), premium grade	Ajouter au panier
GDF-H5119	Human	E. coli	Human GDNF / ATF / hGDNF Protein (E. coli), Research Grade	Ajouter au panier
GDF-H5219	Human	HEK293	Human GDNF / ATF / hGDNF Protein, premium grade	Ajouter au panier
GMP-GDFH17	Human	E. coli	GMP Human GDNF Protein (E. coli)	Ajouter au panier
GDF-M5245	Mouse	HEK293	Mouse GDNF / ATF Protein, His Tag (MALS verified)	Ajouter au panier

Quantité totale5

GDNFContexte de la molécule

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.

GDNFAlias de la molécule

GDNF,ATF

Informations sur les médicaments cliniques

Nom anglais	Code de recherche	Phase de R&D	Entreprise	Indication	Essai clinique
AAV2-GDNF	AB-1005; AMT-140	Phase 2 Clinical	Lund University Foundation, National Institute Of Neurological Disorders And Stroke, Uniqure Biopharma Bv, Uc San Francisco	Parkinson Disease; Multiple System Atrophy	Details
NRO-1	NRO-1; SI-01	Phase 2 Clinical	Senju Pharmaceutical Co Ltd	Xerophthalmia	Details
AMT-130	AAV5-miSNP15; AAV5-miSNP7; AMT-130; AAV5-miHtt12	Phase 2 Clinical	Amsterdam Molecular Therapeutics, Uniqure	Huntington Disease	Details
AAV2-GDNF gene therapy (NINDS)		Phase 1 Clinical	National Institute Of Neurological Disorders And Stroke	Parkinson Disease	Details
RGL-193	RGL-193	Phase 1 Clinical	Shanghai Regenelead Therapies Co Ltd	Parkinson Disease	Details

Avis sur les produits

P***i2025-05-13
0Mettre un like
Human GDNF / ATF / hGDNF Protein, premium grade
Acro Biosystems' GDNF recombinant protein has proven to be a reliable and high-quality reagent for research focused on neuronal development and maturation. In my study involving cortical projection neuron cultures, GDNF consistently supported neuronal survival, neurite outgrowth, and the expression of maturation markers. Its batch-to-batch consistency and biological activity have made it an essential component in our differentiation protocols. I highly recommend this product to laboratories engaged in both fundamental neuroscience research and translational studies aiming to model neurodegenerative diseases or explore neuroprotective strategies.